Term Name: | RQC-trigger complex |
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Synonyms: | activating signal cointegrator 1 complex, RQT complex |
Definition: | A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (human TRIP4). The human complex has an additional component protein ASCC1 and can act as a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. |
Ontology: | GO: Cellular Component [GO:0180022] QuickGO AmiGO |