Term Name: | chromosomal 5-methylcytosine DNA demethylation, oxidative deamination pathway |
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Synonyms: | epigenetic 5-methylcytosine DNA demethylation, oxidative deamination pathway, epigenetic DNA demethylation, oxidative deamination pathway |
Definition: | An epigenetic cytosine DNA demethylation pathway that includes a deamination step to produce either a thymine (T), or a 5-hydroxymethyluracil (5hmU), if the 5meC had first been converted to 5hmC. A DNA glycosylase (e. g. TDG) recognizes the T mispaired with a G or the 5hmC and excises the modified base to initiate its replacement with unmethylated cytosine through base excision repair. |
Ontology: | GO: Biological Process [GO:0141168] QuickGO AmiGO |