Term Name: | piRNA-mediated gene silencing by mRNA destabilization |
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Synonyms: | |
Definition: | A cytoplasmic post-transcriptional gene silencing pathway in which piRNAs direct the cleavage of target mRNAs. The target mRNA, often transcribed from a transposable element, is destabilized by the activity of a PIWI class endonuclease within the piRNA-induced silencing complex. This may also be accompanied by mRNA deadenylation and decapping. |
Ontology: | GO: Biological Process [GO:0140991] QuickGO AmiGO |