Term Name: | transforming growth factor beta complex |
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Synonyms: | TGF-beta complex, TGF-beta dimer, TGFB complex, TGFB dimer, TGFbeta complex, TGFbeta dimer |
Definition: | A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerization and dissociation of the LAP. |
Ontology: | GO: Cellular Component [GO:0099126] QuickGO AmiGO |