Term Name: | interferon regulatory factor complex |
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Synonyms: | IRF complex |
Definition: | A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. |
Ontology: | GO: Cellular Component [GO:0097071] QuickGO AmiGO |