Term Name: | pyroptotic inflammatory response |
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Synonyms: | pyroptosis |
Definition: | A gasdermin-dependent inflammatory response that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. Gasdermins are activated by caspase-1 or caspase-4/11, or by certain granzymes. In some, but not all cells, it can lead to pyroptotic programmed cell death. |
Ontology: | GO: Biological Process [GO:0070269] QuickGO AmiGO |