Term Name: aflatoxin biosynthetic process
Synonyms: aflatoxin anabolism, aflatoxin biosynthesis, aflatoxin formation, aflatoxin synthesis
Definition: The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
Ontology: GO: Biological Process [GO:0045122]    QuickGO    AmiGO

Relationships
has parts: aflatoxin B synthase activity averantin hydroxylase activity
is a type of: acetate metabolic process aflatoxin metabolic process mycotoxin biosynthetic process organic heteropentacyclic compound biosynthetic process
has_part: 5'-hydroxyaverantin dehydrogenase activity aflatoxin B synthase activity averantin hydroxylase activity demethylsterigmatocystin 6-O-methyltransferase activity fatty-acyl-CoA synthase activity norsolorinate anthrone synthase activity norsolorinic acid ketoreductase activity sterigmatocystin 7-O-methyltransferase activity versicolorin B desaturase activity versicolorin B synthase activity versicolorin reductase activity versiconal hemiacetal acetate esterase activity
negatively regulated by: negative regulation of aflatoxin biosynthetic process
positively regulated by: positive regulation of aflatoxin biosynthetic process
regulated by: regulation of aflatoxin biosynthetic process