Term Name: | nuclear SCF ubiquitin ligase complex |
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Synonyms: | nuclear cullin complex, nuclear SCF complex, nuclear Skp1/Cul1/F-box protein complex |
Definition: | A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
Ontology: | GO: Cellular Component [GO:0043224] QuickGO AmiGO |