Term Name: | ERBB2-EGFR signaling pathway |
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Synonyms: | EGFR-HER2 signaling pathway, ERBB2-EGFR signalling pathway |
Definition: | The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR. |
Ontology: | GO: Biological Process [GO:0038134] QuickGO AmiGO |