Term Name: | broad specificity oxidative DNA demethylase activity |
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Synonyms: | 1-ethyladenine demethylase activity, 2-oxoglutarate-dependent DNA demethylase, 5-formylcytosine dioxygenase activity, 5-hydroxymethylcytosine dioxygenase activity, N1-methyladenine demethylase activity, N3-methylcytosine demethylase activity, oxidative DNA demethylase activity |
Definition: | Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA. |
Ontology: | GO: Molecular Function [GO:0035516] QuickGO AmiGO |