Term Name: | miRNA-mediated gene silencing by mRNA destabilization |
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Synonyms: | gene silencing by miRNA, mRNA cleavage, gene silencing by mRNA cleavage, miRNA-mediated gene silencing by mRNA deadenylation, miRNA-mediated gene silencing, mRNA cleavage, mRNA cleavage involved in gene silencing by microRNA, mRNA cleavage involved in gene silencing by miRNA, mRNA destabilization-mediated gene silencing by miRNA |
Definition: | An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism. |
Ontology: | GO: Biological Process [GO:0035279] QuickGO AmiGO |