Term Name: | retromer, tubulation complex |
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Synonyms: | heterodimeric membrane-deforming retromer subcomplex, retromer complex, outer shell, SNX-BAR dimer |
Definition: | The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodeling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6. |
Ontology: | GO: Cellular Component [GO:0030905] QuickGO AmiGO |