Term Name:	midbrain-hindbrain boundary maturation
Synonyms:	isthmus maturation, MHB maturation
Definition:	A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
Ontology:	GO: Biological Process [GO:0021732]    QuickGO    AmiGO