Term Name: | prefoldin complex |
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Synonyms: | GIM complex |
Definition: | A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics. |
Ontology: | GO: Cellular Component [GO:0016272] QuickGO AmiGO |