Term Name:	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
Synonyms:	DNA gyrase inhibitor activity
Definition:	Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
Ontology:	GO: Molecular Function [GO:0008657]    QuickGO    AmiGO