Term Name: | granzyme-mediated apoptotic signaling pathway |
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Synonyms: | apoptotic signaling pathway in response to granzyme, induction of apoptosis by granzyme |
Definition: | The series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells. |
Ontology: | GO: Biological Process [GO:0008626] QuickGO AmiGO |