Term Name: | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity |
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Synonyms: | 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase, 3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity, 3-OST-1 activity, glucosaminyl 3-O-sulfotransferase activity, heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity, heparin-glucosamine 3-O-sulfotransferase activity, heparin-glucosamine 3-O-sulphotransferase activity, isoform/isozyme 1 (3-OST-1, HS3ST1) |
Definition: | Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 3-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+. The (heparan sulfate)-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. |
Ontology: | GO: Molecular Function [GO:0008467] QuickGO AmiGO |