Term Name: | I-kappaB phosphorylation |
---|---|
Synonyms: | IkappaB phosphorylation, IKB phosphorylation, inhibitor of kappaB phosphorylation, inhibitor of NF-kappaB phosphorylation |
Definition: | The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
Ontology: | GO: Biological Process [GO:0007252] QuickGO AmiGO |