Term Name: | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
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Synonyms: | mRNA breakdown, nonsense-mediated decay, mRNA catabolic process, nonsense-mediated, mRNA catabolism, nonsense-mediated, mRNA degradation, nonsense-mediated decay, nonsense-mediated mRNA decay, nuclear mRNA catabolic process, nonsense-mediated decay |
Definition: | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
Ontology: | GO: Biological Process [GO:0000184] QuickGO AmiGO |