Term Name:	major depressive disorder
Synonyms:	major depression, recurrent major depression, single major depressive episode
Definition:	A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.
Ontology:	Human Disease [DOID:1470]   ( DOID:1470 )