Term Name:	adult-onset autosomal dominant demyelinating leukodystrophy
Synonyms:	ADLD, adult-onset autosomal dominant leukodystrophy, autosomal-dominant or late-onset type Pelizaeus-Merzbacher disease
Definition:	A leukodystrophy characterized by onset in the 4th or 5th decade of life of autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS that has_material_basis_in heterozygous tandem genomic duplication resulting in an extra copy of the LMNB1 gene on chromosome 5q.
Ontology:	Human Disease [DOID:0060785]   ( DOID:0060785 )