Term Name: | pre-B-I cell |
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Synonyms: | pre-BI cell, pro-B cell (Philadelphia nomenclature) |
Definition: | A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein. |
Ontology: | Cell Ontology [CL:0000956] |