Term Name: | sotrastaurin |
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Synonyms: | 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione, AEB 071, AEB-071, AEB071, sotrastaurin, sotrastaurina, sotrastaurine, sotrastaurinum |
Definition: | A member of the class of maleimides that is maleimide which is substituted at position 3 by an indol-3-yl group and at position 4 by a quinazolin-4-yl group, which in turn is substituted at position 2 by a 4-methylpiperazin-1-yl group. It is a potent and selective inhibitor of protein kinase C and has been investigated as an immunosuppresant in renal transplant patients. |
Ontology: | ChEBI [CHEBI:90531] ( EBI ) |