Term Name: | CD437 |
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Synonyms: | 6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid, 6-[4-hydroxy-3-(tricyclo[3.3.1.1(3,7)]dec-1-yl)phenyl]-2-naphthalenecarboxylic acid, 6-[4-hydroxy-3-(tricyclo[3.3.1.1(3,7)]dec-1-yl)phenyl]naphthalene-2-carboxylic acid, AHPN, Apoptosis Activator VI, Cd 437, CD-437 |
Definition: | A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)gamma and induces cell cycle arrest and apoptosis in various cancer cells. |
Ontology: | ChEBI [CHEBI:88334] ( EBI ) |