Term Name: | Src Inhibitor-1 |
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Synonyms: | (4'-oxyphenyl-phenylamino)-6,7-dimethoxyquinazoline, 4-(4'-phenoxyanilino)-6,7-dimethoxyquinazoline, 6,7-dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine, 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine, SKI-1, Src kinase inhibitor I, Src-l1 |
Definition: | A member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. |
Ontology: | ChEBI [CHEBI:78332] ( EBI ) |