Term Name: | nemonapride |
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Synonyms: | (+-)-cis-N-(1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-4-(methylamino)-o-anisamide, (+-)-cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide, (+-)-nemonapride, Emilace, emonapride, nemonaprida, nemonapride, nemonapridum, rac-N-[(2S,3S)-1-benzyl-2-methylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(methylamino)benzamide, rac-nemonapride, racemic nemonapride, YM 09151-2, YM-09151 |
Definition: | A racemate composed of (2S,3S)- and (2R,3R)-enantiomers of nemonapride. Highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors. |
Ontology: | ChEBI [CHEBI:31899] ( EBI ) |