Term Name: | angiotensin I |
---|---|
Synonyms: | angiotensin I, Angiotonin, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, D-R-V-Y-I-H-P-F-H-L, DRVYIHPFHL, Hypertensin, L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine, L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-His-L-Leu, pepsitensin, proangiotensin |
Definition: | A ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids. |
Ontology: | ChEBI [CHEBI:2718] ( EBI ) |