| Synonyms: |
AR-00334543,
AR00334543,
ARRY 334543,
ARRY-334543,
ARRY-543,
ASLAN-001,
ASLAN001,
N(4)-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-N(6)-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine,
varlitinib,
varlitinibum
|
| Definition: |
A member of the class of quinazolines that is quinazoline substituted by {3-chloro-4-[(1,3-thiazol-2-yl)methoxy]phenyl}amino and [(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]amino groups at positions 4 and 6, respectively. It is a tyrosine kinase inhibitor of both ErbB-2 (Her-2/neu) and EGFR and has shown significant anti-tumour activity in preclinical models of human breast, lung, and epidermal carcinoma tumours. |