Term Name: | midafotel |
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Synonyms: | (2R)-4-[(2E)-3-phosphono-2-propenyl]-2-piperazinecarboxylic acid, (2R)-4-[(2E)-3-phosphonoprop-2-en-1-yl]piperazine-2-carboxylic acid, (R)-4-[(E)-3-phosphonoprop-2-enyl]piperazine-2-carboxylic acid, (R)-CPP-ene, D(-)CPPene, D-4-[(2E)-3-phosphono-2-propenyl]-2-piperazinecarboxylic acid, D-CPP-ene, D-CPPene, midafotel, midafotelum, SDZ EAA 494, SDZ-EAA 494, SDZ-EAA-494 |
Definition: | A member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and was in clinical development by Novartis for the treatment of cognition disorders and brain injuries (now discontinued). |
Ontology: | ChEBI [CHEBI:180900] ( EBI ) |