Term Name: | RSL3 |
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Synonyms: | (1S,3R)-RSL3, methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,4a,9,9a-hexahydro-1H-beta-carboline-3-carboxylate, ras-selective lethal small molecule 3 |
Definition: | A beta-carboline that is 2,3,4,4a,9,9a-hexahydro-1H-beta-carboline in which the hydrogens at positions 1, 2 and 3 are replaced by 4-(methoxycarbonyl)phenyl, chloroacetyl and methoxycarbonyl groups, respectively (the 1S,2R stereoisomer). It is a potential antineoplastic agent which triggers ferroptosis by inactivating the glutathione peroxidase 4 (GPX4) enzyme. |
Ontology: | ChEBI [CHEBI:173109] ( EBI ) |