Term Name: | KOM70144 |
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Synonyms: | (R)-5-acetamido-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide, 5-(acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide, 5-acetamido-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, 5-N-acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide |
Definition: | A benzamide that is GRL-0617 in which one of the hydrogen's of the primary amino group is replaced by an acetyl group. It an inhibitor of SARS-CoV and SARS-CoV-2 papain-like protease (PLpro) with an IC50 of 2.6 muM and 5.0 muM, respectively. It also inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC50 values are 13.1 and 21 muM, respectively). |
Ontology: | ChEBI [CHEBI:167314] ( EBI ) |