| Term: | cerebrospinal fluid contacting neuron apical junction complex |
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| Note: | This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name. |
| Name: | cerebrospinal fluid contacting neuron |
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| Synonyms: | CSF-cN, CSF-cNs |
| Definition: | Spinal cord interneuron located along the central canal that extends a microvilliated apical process into the cerebrospinal fluid and extends ascending axonal projections ventrally and ipsilaterally. CSF-cNs are GABAergic neurons that express PKD2L1 (TRPP3) channels and have been shown to be chemosensory and mechanosensory, responding to pH and osmolarity changes as well as mechanical stimuli associated with tail bending. CSF-cNs originate from two distinct progenitor domains, p3 and pMN. CSF-cNs project onto caudal primary (CaP motor neurons) and commissural primary ascending (CoPA) sensory interneurons within the escape circuit as well as onto V0-v interneurons within the slow swimming circuit. |
| Ontology: | Anatomy Ontology [ZFA:0007120] |
| Name: | apical junction complex |
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| Synonyms: | apical cell junction complex, apical junction |
| Definition: | A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. |
| Ontology: | GO: Cellular Component [GO:0043296] QuickGO AmiGO |