| Term: | cerebrospinal fluid contacting neuron adherens junction |
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| Note: | This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name. |
| Name: | cerebrospinal fluid contacting neuron |
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| Synonyms: | CSF-cN, CSF-cNs |
| Definition: | Spinal cord interneuron located along the central canal that extends a microvilliated apical process into the cerebrospinal fluid and extends ascending axonal projections ventrally and ipsilaterally. CSF-cNs are GABAergic neurons that express PKD2L1 (TRPP3) channels and have been shown to be chemosensory and mechanosensory, responding to pH and osmolarity changes as well as mechanical stimuli associated with tail bending. CSF-cNs originate from two distinct progenitor domains, p3 and pMN. CSF-cNs project onto caudal primary (CaP motor neurons) and commissural primary ascending (CoPA) sensory interneurons within the escape circuit as well as onto V0-v interneurons within the slow swimming circuit. |
| Ontology: | Anatomy Ontology [ZFA:0007120] |
| Name: | adherens junction |
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| Synonyms: | cell-cell adherens junction |
| Definition: | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| Ontology: | GO: Cellular Component [GO:0005912] QuickGO AmiGO |