| ZFIN ID: ZDB-EXP-220623-4 |
Experiment Conditions Description: chemical treatment by environment: olaparib, chemical treatment by environment: rubitecan
| chemical treatment by environment: olaparib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | olaparib |
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| Synonyms: | 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one, AZD-2281, AZD2281, KU59436, Lynparza, olaparib |
| Definition: | A member of the class of N-acylpiperazines obtained by formal condensation of the carboxy group of 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoic acid with the free amino group of N-(cyclpropylcarbonyl)piperazine; used to treat advanced ovarian cancer. |
| Ontology: | ChEBI [CHEBI:83766] ( EBI ) |
| chemical treatment by environment: rubitecan |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | rubitecan |
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| Synonyms: | (4S)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-NC, 9-nitro-(20S)-camptothecin, 9-nitro-20(S)-camptothecin, 9-nitrocamptothecin, Camptogen, Orathecin, RFS 2000, rubitecan, rubitecanum |
| Definition: | A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin. |
| Ontology: | ChEBI [CHEBI:90225] ( EBI ) |
| Publication: | Tsikarishvili et al., 2021 |
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