| chemical treatment by environment: 4-phenylbutyric acid |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | 4-phenylbutyric acid |
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| Synonyms: | 4-PHENYL-BUTANOIC ACID, 4-Phenyl-n-butyric acid, 4-phenylbutanoic acid, Benzenebutyric acid, gamma-Phenyl-n-butyric acid, gamma-phenylbutyric acid, omega-Phenylbutanoic acid, omega-phenylbutyric acid, PBA |
| Definition: | A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation. |
| Ontology: | ChEBI [CHEBI:41500] ( EBI ) |