| chemical treatment by environment: EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor |
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| Synonyms: | ADP-ribosyltransferase (polymerising) inhibitor, ADP-ribosyltransferase (polymerising) inhibitors, ADP-ribosyltransferase (polymerizing) inhibitor, ADP-ribosyltransferase (polymerizing) inhibitors, EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitors, EC 2.4.2.30 inhibitor, EC 2.4.2.30 inhibitors, NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitor, NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitors, NAD(+) ADP-ribosyltransferase inhibitor, NAD(+) ADP-ribosyltransferase inhibitors, NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor, NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors, NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor, NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors, PARP, PARPs, poly(adenosine diphosphate ribose) polymerase inhibitor, poly(adenosine diphosphate ribose) polymerase inhibitors, poly(ADP-ribose) polymerase inhibitor, poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) synthase inhibitor, poly(ADP-ribose) synthase inhibitors, poly(ADP-ribose) synthetase inhibitor, poly(ADP-ribose) synthetase inhibitors |
| Definition: | An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of a NAD(+) ADP-ribosyltransferase (EC 2.4.2.30). |
| Ontology: | ChEBI [CHEBI:62913] ( EBI ) |
| chemical treatment by environment: metronidazole |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | metronidazole |
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| Synonyms: | 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole, 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole, 1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-oxyethyl)-2-methyl-5-nitroimidazole, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol, 2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole, 2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole, 2-methyl-5-nitroimidazole-1-ethanol, metronidazol, metronidazole, metronidazolum |
| Definition: | A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. |
| Ontology: | ChEBI [CHEBI:6909] ( EBI ) |