| viral treatment by injection: Sprivivirus cyprinus |
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| Name: | viral treatment by injection |
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| Synonyms: | |
| Definition: | Viral treatment where the virus is injected into the fish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000235] |
| Name: | Sprivivirus cyprinus |
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| Synonyms: | Carp sprivivirus, Rhabdovirus carpio, Spring viraemia of carp virus, Spring viremia of carp virus, Sprivirus cyprinus, SVC |
| Definition: | |
| Ontology: | Taxonomy for ZECO [NCBITaxon:696863] |
| chemical treatment by environment: pevonedistat |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | pevonedistat |
|---|---|
| Synonyms: | [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxy-cyclopentyl]methyl sulfamate, [(1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate, MLN 4924, MLN-4924, MLN4924, pevonedistat, pevonedistatum |
| Definition: | A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes. |
| Ontology: | ChEBI [CHEBI:145535] ( EBI ) |