Conditions: chemical ablation: T cell, chemical treatment by environment: metronidazole, transection: spinal cord
transection: spinal cord
Name: transection
Synonyms:
Definition: Cutting transversly of an organ or tissue. Type of cutting often used to divide the spinal cord to investigate neural regeneration in zebrafish.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000181]
Name: spinal cord
Synonyms: medulla spinalis, spinal cord structure
Definition:
Ontology: Anatomy Ontology [ZFA:0000075]
chemical ablation: T cell
Name: chemical ablation
Synonyms:
Definition: Experimental condition which uses a chemical to ablate an anatomical structure or cell.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000169]
Name: T cell
Synonyms: immature T cell, immature T lymphocyte, immature T-cell, immature T-lymphocyte, mature T cell, mature T lymphocyte, mature T-cell, mature T-lymphocyte, T lymphocyte, T-cell, T-lymphocyte
Definition: A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
Ontology: Anatomy Ontology [ZFA:0009046]
chemical treatment by environment: metronidazole
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: metronidazole
Synonyms: 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole, 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole, 1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-oxyethyl)-2-methyl-5-nitroimidazole, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol, 2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole, 2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole, 2-methyl-5-nitroimidazole-1-ethanol, metronidazol, metronidazole, metronidazolum
Definition: A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Ontology: ChEBI [CHEBI:6909]  ( EBI )