chemical ablation: insulin secreting cell

Name:	chemical ablation
Synonyms:
Definition:	Experimental condition which uses a chemical to ablate an anatomical structure or cell.
Ontology:	Zebrafish Environment Condition Ontology [ZECO:0000169]

Name:	insulin secreting cell
Synonyms:	insulin secreting cells
Definition:
Ontology:	Anatomy Ontology [ZFA:0009101]

chemical treatment: all-trans-retinoic acid

Name:	chemical treatment
Synonyms:
Definition:	Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology:	Zebrafish Environment Condition Ontology [ZECO:0000111]

Name:	all-trans-retinoic acid
Synonyms:	(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid, (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid, (all-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-all-trans-tetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2E,4E,6E,8E-tetraenoic acid, Acide retinoique (French), AGN 100335, all-(E)-retinoic acid, all-trans retinoic acid, all-trans-beta-Retinoic acid, all-trans-retinoic acid, all-trans-tretinoin, all-trans-vitamin A acid, all-trans-vitamin A1 acid, Altreno, Atralin, Avita, beta-Retinoic acid, Betarretin, Biacna, Cordes vas, Dermairol, Refissa, Renova, Retin-A, retinoic acid, Retisol-A, Ro 1-5488, Stieva-A, trans-retinoic acid, Tretin M, tretinoin, tretinoina, tretinoine, tretinoinum, Tri-luma, Veltin, Vesanoid, vitamin A acid
Definition:	A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Ontology:	ChEBI [CHEBI:15367] ( EBI )

chemical treatment: metronidazole

Name:	chemical treatment
Synonyms:
Definition:	Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology:	Zebrafish Environment Condition Ontology [ZECO:0000111]

Name:	metronidazole
Synonyms:	1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole, 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole, 1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-oxyethyl)-2-methyl-5-nitroimidazole, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol, 2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole, 2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole, 2-methyl-5-nitroimidazole-1-ethanol, metronidazol, metronidazole, metronidazolum
Definition:	A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Ontology:	ChEBI [CHEBI:6909] ( EBI )