| Phenotype: | receptor internalization increased occurrence, ameliorated |
|---|---|
| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | receptor internalization |
|---|---|
| Synonyms: | |
| Definition: | A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. |
| Ontology: | GO: Biological Process [GO:0031623] QuickGO AmiGO |
| Name: | increased occurrence |
|---|---|
| Synonyms: | increased incidence |
| Definition: | An occurrence which is relatively high. |
| Ontology: | Phenotypic Quality Ontology [PATO:0002051] |
| Tag: | ameliorated |
|---|---|
| Definition: | This annotation denotes a significantly rescued phenotype resulting from an additional reagent or mutation. |