| Phenotype: | cholangiocyte Wnt signaling pathway increased occurrence, abnormal |
|---|---|
| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | cholangiocyte |
|---|---|
| Synonyms: | bile duct cells, epithelial cell of bile duct |
| Definition: | An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. |
| Ontology: | Anatomy Ontology [ZFA:0009397] |
| Name: | Wnt signaling pathway |
|---|---|
| Synonyms: | frizzled signaling pathway, frizzled signalling pathway, Wg signaling pathway, Wg signalling pathway, Wingless signaling pathway, Wingless signalling pathway, Wnt receptor signaling pathway, Wnt receptor signalling pathway, Wnt-activated signaling pathway |
| Definition: | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. |
| Ontology: | GO: Biological Process [GO:0016055] QuickGO AmiGO |
| Name: | increased occurrence |
|---|---|
| Synonyms: | increased incidence |
| Definition: | An occurrence which is relatively high. |
| Ontology: | Phenotypic Quality Ontology [PATO:0002051] |