| Phenotype: | MAP kinase activity increased occurrence, abnormal |
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| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | MAP kinase activity |
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| Synonyms: | ATP:protein phosphotransferase (MAPKK-activated) activity, ERK, ERK1, ERK2, extracellular signal-regulated kinase activity, MAP kinase 1 activity, MAP kinase 2 activity, MAPK, MBP kinase I activity, MBP kinase II activity, mitogen activated kinase activity, mitogen-activated protein kinase activity, myelin basic protein kinase activity, SAP kinase activity, SAPK, stress-activated kinase activity, stress-activated protein kinase activity |
| Definition: | Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. |
| Ontology: | GO: Molecular Function [GO:0004707] QuickGO AmiGO |
| Name: | increased occurrence |
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| Synonyms: | increased incidence |
| Definition: | An occurrence which is relatively high. |
| Ontology: | Phenotypic Quality Ontology [PATO:0002051] |