Phenotype: integument canonical NF-kappaB signal transduction increased process quality, abnormal
Note: This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name.
Name: integument
Synonyms: skin
Definition: The outer protective barrier that separates the animal from its aquatic environment.
Ontology: Anatomy Ontology [ZFA:0000368]
Name: canonical NF-kappaB signal transduction
Synonyms: activation of the inhibitor of kappa kinase, canonical NF-kappaB signaling cascade, I-kappaB kinase/NF-kappaB cascade, I-kappaB kinase/NF-kappaB signal transduction, I-kappaB kinase/NF-kappaB signaling, NF-kappaB cascade, p50-dependent NF-kappaB signaling
Definition: An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).
Ontology: GO: Biological Process [GO:0007249]    QuickGO    AmiGO
Name: increased process quality
Synonyms:
Definition: A quality of a process that has a value that is increased compared to normal or average.
Ontology: Phenotypic Quality Ontology [PATO:0002304]