| Phenotype: | hepatocyte nuclear lamina Ab2-lmnb2 labeling decreased amount, abnormal |
|---|---|
| Note: | This phenotype statement describes a gene expression or antibody labeling pattern. Anatomy terms are combined with a gene or antibody and phenotype quality. |
EXPRESSION ANATOMY:
| Name: | hepatocyte |
|---|---|
| Synonyms: | hepatocytes |
| Definition: | The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. |
| Ontology: | Anatomy Ontology [ZFA:0009111] |
| Name: | nuclear lamina |
|---|---|
| Synonyms: | |
| Definition: | The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane. |
| Ontology: | GO: Cellular Component [GO:0005652] QuickGO AmiGO |
ANTIBODY LABELING:
EXPRESSION QUALITY:
| Name: | decreased amount |
|---|---|
| Synonyms: | decreased, decreased number, present in fewer numbers in organism, reduced, subnumerary |
| Definition: | An amount which is relatively low. |
| Ontology: | Phenotypic Quality Ontology [PATO:0001997] |