| Phenotype: | cerebrospinal fluid contacting neuron urp1 expression decreased distribution, abnormal |
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| Note: | This phenotype statement describes a gene expression or antibody labeling pattern. Anatomy terms are combined with a gene or antibody and phenotype quality. |
EXPRESSION ANATOMY:
| Name: | cerebrospinal fluid contacting neuron |
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| Synonyms: | CSF-cN, CSF-cNs |
| Definition: | Spinal cord interneuron located along the central canal that extends a microvilliated apical process into the cerebrospinal fluid and extends ascending axonal projections ventrally and ipsilaterally. CSF-cNs are GABAergic neurons that express PKD2L1 (TRPP3) channels and have been shown to be chemosensory and mechanosensory, responding to pH and osmolarity changes as well as mechanical stimuli associated with tail bending. CSF-cNs originate from two distinct progenitor domains, p3 and pMN. CSF-cNs project onto caudal primary (CaP motor neurons) and commissural primary ascending (CoPA) sensory interneurons within the escape circuit as well as onto V0-v interneurons within the slow swimming circuit. |
| Ontology: | Anatomy Ontology [ZFA:0007120] |
EXPRESSED GENE:
| Symbol: | urp1 | ||||||||||||
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| Name: | urotensin-related peptide 1 | ||||||||||||
| Previous Name: | si:ch73-335m24.4 (1) | ||||||||||||
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Attributions for Alias: {{control.newAlias}}
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| Location: | Chr: 14 Mapping Details/Browsers | ||||||||||||
EXPRESSION QUALITY:
| Name: | decreased distribution |
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| Synonyms: | low distribution |
| Definition: | A distribution which is relatively low. |
| Ontology: | Phenotypic Quality Ontology [PATO:0001672] |