Search Ontology:
GO: Biological Process

ERK1 and ERK2 cascade

Term ID
GO:0070371
Synonyms
  • ERK cascade
  • ERK1 and ERK2 signaling pathway
  • ERK1 and ERK2 signalling pathway
  • ERK1 cascade
  • ERK1/2 cascade
  • ERK2 cascade
  • extracellular signal-regulated kinase 1/2 (ERK1/2) cascade
  • extracellular signal-regulated kinase 1/2 cascade
  • MAPK1 cascade
  • MAPK3 cascade
Definition
A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development. (3)
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
is a type of
negatively regulated by
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes