lysine biosynthetic process via alpha-aminoadipate and saccharopine

Term ID

GO:0051975

Synonyms

• lysine biosynthesis via aminoadipic acid and saccharopine
• lysine biosynthetic process via aminoadipic acid and saccharopine

Definition

The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine.

References

• MetaCyc:LYSINE-AMINOAD-PWY

Ontology

GO: Biological Process    QuickGO    AmiGO