Search Ontology:
GO: Molecular Function

deoxyhypusine synthase activity

Term ID
GO:0034038
Synonyms
  • (4-aminobutyl)lysine synthase
  • eIF-5A-deoxyhypusine synthase activity
  • spermidine dehydrogenase
Definition
Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+.
References
  • EC:2.5.1.46
  • MetaCyc:2.5.1.46-RXN
  • RHEA:33299
  • Reactome:R-HSA-204617
  • Reactome:R-HSA-204647
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
is a type of
Phenotype
Phenotype caused by Genes