Search Ontology:
GO: Molecular Function

methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity

Term ID
GO:0004491
Synonyms
  • methylmalonate-semialdehyde dehydrogenase (acylating) activity
  • MMSA dehydrogenase activity
  • MSDH activity
Definition
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product. (2)
References
  • EC:1.2.1.27
  • MetaCyc:1.2.1.27-RXN
  • Reactome:R-HSA-70893
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
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Phenotype
Phenotype caused by Genes