Search Ontology:
ChEBI
PF-3758309
- Term ID
- CHEBI:93751
- Synonyms
-
- N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
- PF 309
- PF 3758309
- PF-03758309
- PF-309
- PF309
- PF3758309
- Definition
- A member of the class of thienopyrimidines that is thieno[3,2-d]pyrimidine substituted by methyl and (5-{[(1S)-2-(dimethylamino)-1-phenylethyl]carbamoyl}-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)amino groups at positions 2 and 4, respectively. It is a potent inhibitor of PAK4 and inhibits the growth of multiple human tumor xenografts.
- References
-
- CAS:898044-15-0
- DrugBank:DB11775
- LINCS:LSM-4254
- PDBeChem:7KC
- PMID:20439741
- PMID:23524533
- PMID:23543898
- PMID:24204982
- PMID:24366569
- PMID:24432870
- PMID:25640698
- PMID:29048629
- PMID:29191878
- PMID:30455231
- PMID:31312349
- PMID:31595158
- PMID:32469945
- PMID:32829006
- PMID:33414491
- PMID:33987822
- PMID:35401439
- PMID:35939342
- PMID:36240067
- PMID:36671485
- PMID:37258566
- PMID:37564209
- PMID:37568037
- PMID:37864885
- PMID:38336988
- PMID:38885414
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Show All 6 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from PF-3758309
Phenotype where environments contain PF-3758309
Phenotype modified by environments containing PF-3758309
Human Disease / Model Data